These coats of skin had a significancy. The beasts whose skins they were, must be slain; slain before their eyes to shew them what death is. And probably 'tis supposed they were slain for sacrifice, to typify the great sacrifice which in the latter end of the world should be offered once for all. Thus the first thing that died was a sacrifice, or Christ in a figure.
Related Commentaries of Genesis 3:21
Genesis 3:21
21 Unto Adam also and to his wife did the LORD God make coats of skins, and clothed them.