We are very guilty concerning our brother — We do not read that they said this during their three days imprisonment; but now when the matter was come to some issue, and they saw themselves still embarrassed, they began to relent. Perhaps Joseph's mention of the fear of God, put them upon consideration, and extorted this reflexion.
Related Commentaries of Genesis 42:21
Genesis 42:21
21 And they said one to another, We are verily guilty concerning our brother, in that we saw the anguish of his soul, when he besought us, and we would not hear; therefore is this distress come upon us.