Genesis 6:6 - Wesley's Explanatory Notes

And it repented the Lord that he had made man upon the earth — That he had made a creature of such noble powers, and had put him on this earth, which he built and furnished on purpose to be a comfortable habitation for him; and it grieved him at his heart — These are expressions after the manner of men, and must be understood so as not to reflect upon God's immutability or felicity. It doth not speak any passion or uneasiness in God, nothing can create disturbance to the eternal mind; but it speaks his just and holy displeasure against sin and sinners: neither doth it speak any change of God's mind; for with him there is no variableness; but it speaks a change of his way. When God had made man upright, he rested and was refreshed, Exodus 31:17. and his way towards him was such as shewed him well pleased with the work of his own hands; but now man was apostatized, he could not do otherwise, but shew himself displeased; so that the change was in man, not in God.