Those whom thou hast given me I have guarded, and none of them is lost, but the son of perdition — So one even of them whom God had given him is lost. So far was even that decree from being unchangeable! That the Scripture might be fulfilled — That is, whereby the Scripture was fulfilled. The son of perdition signifies one that deservedly perishes; as a son of death, 2 Samuel 12:5; children of hell, Matthew 23:15, and children of wrath, Ephesians 2:3, signify persons justly obnoxious to death, hell, wrath. Psalms 109:8.
Related Commentaries of John 17:12
John 17:12
12 While I was with them in the world, I kept them in thy name: those that thou gavest me I have kept, and none of them is lost, but the son of perdition; that the scripture might be fulfilled.