Estranged — From God, and from all goodness. Their very natures are corrupt, even from their birth: they are the wicked offspring of sinful parents. Astray — By actual sins, from their childhood, as soon as ever they were capable of the exercise of reason.
Related Commentaries of Psalms 58:3
Psalms 58:3
3 The wicked are estranged from the womb: they go astray as soon as they be born, speaking lies.