Son of man set thy face against Mount Seir,.... Which had its name from Seir the Horite, who first possessed it; and was succeeded in it by Esau and his posterity, the Edomites; see Genesis 36:8 Deuteronomy 2:12, so that the country of Edom or Idumea is here intended, and the inhabitants of it; who are put for the enemies of the church and people of God in general, as these were the enemies of Israel and Judah; and particularly for Rome, which, as it was spiritually called Egypt and Sodom, so it may be called Edom, as it often is by the Jews: now the prophet is bid to turn his face towards this mountain or country, and look sternly at it, and severely threaten it. The Targum is,
"take up a prophecy against it;''
which is expressed in the next clause:
and prophesy against it; foretell things contrary to it, which relate to its destruction, as follows: