And they shall teach my people the difference between the holy and the profane,.... Persons and things; not in a ceremonial, nor merely in a moral, but in an evangelical sense, between truth and error; between the doctrine which is according to godliness, and that which is corrupt and unsound, and eats as cloth a canker; between holy worship, and superstition; between holy duties, and profane and Heathen rites and ceremonies; and between persons sanctified by the Spirit and grace of God, and unconverted ones:
and cause them to discern between the unclean and the clean; impure persons, doctrines, and manners, and those which are agreeable to the word of God; the sense is, that they shall take pains to instruct persons in the knowledge of divine things, and shall do it truly, faithfully, and sincerely.