And it shall come to pass in that day,.... When the vials are pouring out:
[that] a great tumult from the Lord shall be among them; the Targum renders it, a great tumult, or noise of killing; and the Septuagint, an ecstasy: it refers to the earthquake, and the slaughter of seven thousand men of name, and the fright upon that, Revelation 11:13
and they shall lay hold everyone on the hand of his neighbour, and shall rise up against the hand of his neighbour; there will be a revolution, upon this tumult, in several of the antichristian states; and the kings of them shall hate the whore, make her desolate, eat her flesh, and burn her with fire, Revelation 17:16 or, "his hand shall be cut off by the hand of his neighbour" u; see Zechariah 11:17, the power of antichrist shall be destroyed by neighbouring Christian princes.
u ועלתה ידו על יד רעהו "et succidetur manus ejus super manum amici sui", Pagninus. So Aben Ezra, and R. Sol. Urbin. Ohel Moed, fol. 43. 1.