And when he shall stand up, his kingdom shall be broken, and shall be divided toward the four winds of heaven; and not to his posterity, nor according to his dominion which he ruled: for his kingdom shall be plucked up, even for others beside those. His kingdom shall be broken - Shall, after his death, be divided among his four chief generals, as we have seen before. See Daniel 8:22.
And not to his posterity - The family of Alexander had a most tragical end:
1. His wife Statira was murdered soon after his death by his other wife Roxana.
2. His brother Aridaeus who succeeded him, was killed, together with his wife Euridice, by command of Olympias, Alexander's mother, after he had been king about six years and some months.
3. Olympias herself was killed by the soldiers in revenge.
4. Alexander Aegus, his son, together with his mother Roxana, was slain by order of Cassander.
5. Two years after, his other son Hercules, with his mother Barsine, was privately murdered by Polysperchon; so that in fifteen years after his death not one of his family or posterity remained alive!
"Blood calls for blood." He (Alexander) was the great butcher of men. He was either poisoned, or killed himself by immoderate drinking, when he was only thirty-two years and eight months old: and a retributive Providence destroyed all his posterity, so that neither root nor branch of them was left on the face of the earth. Thus ended Alexander, the great butcher; and thus ended his family and posterity.