For whosoever shall do the will of my Father which is in heaven, the same is my brother, and sister, and mother. Whosoever shall do the will of my Father, etc. - Those are the best acknowledged relatives of Christ who are united to him by spiritual ties, and who are become one with him by the indwelling of his Spirit. We generally suppose that Christ's relatives must have shared much of his affectionate attention; and doubtless they did: but here we find that whosoever does the will of God is equally esteemed by Christ, as his brother, sister, or even his virgin mother. What an encouragement for fervent attachment to God!
1. From various facts related in this chapter, we see the nature and design of the revelation of God, and of all the ordinances and precepts contained in it - they are all calculated to do man good: to improve his understanding, to soften and change his nature, that he may love his neighbor as himself. That religion that does not inculcate and produce humanity never came from heaven.
2. We have already seen what the sin against the Holy Ghost is: no soul that fears God can commit it: perhaps it would be impossible for any but Jews to be guilty of it, and they only in the circumstances mentioned in the text; and in such circumstances, it is impossible that any person should now be found.
Commentary on the Bible, by Adam Clarke [1831].