The same shall drink of the wine of the wrath of God, which is poured out without mixture into the cup of his indignation; and he shall be tormented with fire and brimstone in the presence of the holy angels, and in the presence of the Lamb: The wine of the wrath of God - As they have drunk the intoxicating wine of idolatry or spiritual fornication, they shall now drink the wine of God's wrath, which is poured out into the cup of his indignation. This is an allusion to the poisoned cup, which certain criminals were obliged to drink, on which ensued speedy death. See on Hebrews 2:9 (note).
Shall be tormented with fire and brimstone - An allusion to the punishment of Sodom and Gomorrha for their unnatural crimes.
Presence of the holy angels, and - of the Lamb - These being the instruments employed in their destruction; the Lamb - the Lord Jesus Christ, acting as judge.