And the seventh angel poured out his vial into the air; and there came a great voice out of the temple of heaven, from the throne, saying, It is done. Poured out his vial into the air - To signify that this plague was to be widely diffused, and perhaps to intimate that pestilences and various deaths would be the effect of this vial. But possibly air in this place may have some emblematical meaning.
It is done - It is said, Revelation 10:7, that in the days of the seventh trumpet the mystery of God should be finished; so here we find it completed. Γεγονε· All's over! Fuimus Troes! Ilium fuit! Once there were Trojans, and they had a city; but now all are extinct.