And the great city was divided into three parts, and the cities of the nations fell: and great Babylon came in remembrance before God, to give unto her the cup of the wine of the fierceness of his wrath. The great city - Some say Jerusalem, others Rome pagan, others Rome papal.
The cup of the wine of the fierceness of his wrath - Alluding to the mode of putting certain criminals to death, by making them drink a cup of poison. See on Hebrews 2:9 (note).