Which none of the princes of this world knew: for had they known it, they would not have crucified the Lord of glory.
Which - wisdom: the strongest proof of the natural man's destitution of heavenly wisdom.
The princes of this world. Herod, Pilate, Annas, and Caiaphas represent the worldly great in church and state, philosophers and rhetoricians.
Crucified the Lord of glory - implying the inseparable connection of Christ's humanity and His divinity. "The Lord of glory" (which He had in His own right before the world was, John 17:4; John 17:24) was "crucified." The Son has the Father's title, comprehending all the fullness of the Godhead (Acts 7:2; Ephesians 1:17; Psalms 24:7, Melek (H4428) hakabowd. (H3519)