We are fools for Christ's sake, but ye are wise in Christ; we are weak, but ye are strong; ye are honourable, but we are despised.
Irony. How much your lot (supposing it to be real) is to be envied, and ours to be pitied!
Fools (1 Corinthians 1:21; 1 Corinthians 3:18: cf. Acts 17:18; Acts 26:24) for Christ's sake ... in Christ - our union with Christ only entails on us, "FOR THE SAKE OF" Him, reproach as "fools;" yours gives you full fellowship IN Him as "wise" (i:e., supposing you really are all you seem, 1 Corinthians 3:18).
We are weak, but ye are strong (1 Corinthians 2:3; 2 Corinthians 13:9) - in a worldly point of view (1 Corinthians 4:9); but contrast 2 Corinthians 12:9-10; Revelation 3:17-18.
We are despised (2 Corinthians 10:10) - because of our "weakness," and our not using worldly philosophy and rhetoric, while ye Corinthians and your teachers are (seemingly) so "honourable." Contrast with "despised," Galatians 4:14.