Now the Lord of peace himself give you peace always by all means. The Lord be with you all.
Lord of peace - Jesus Christ. The same title is given to Him as to the Father (Romans 15:33; Romans 16:20; 2 Corinthians 13:11). An appropriate title here, where the harmony of the Christian community was liable to interruption from the "disorderly" (1 Thessalonians 5:23; Philippians 4:7). Greek, 'give you the peace' which it is 'His to give.' "Peace" outward and inward, with God, with one another, with the world, here and hereafter (Romans 14:17). Isaiah 26:3, 'The deep tranquillity of a soul resting on God' (Ellicott).
Always - not changing with outward circumstances.
By all means - Greek, 'in every way.' [So 'Aleph (') B, tropoo (G5158). But A Delta G f g, Vulgate, topoo (G5117).] 'In every place:' thus he prays for their peace in all times ('always') and places.
Lord be with you all. May He bless you not only with peace, but also with His presence (Matthew 28:20). Even the disorderly brethren (cf. 2 Thessalonians 3:15, "a brother") are included in this prayer.