Grace be with you - plural; i:e., thee and the members of the Ephesian and neighbouring churches.
Related Commentaries of 2 Timothy 4:22
2 Timothy 4:22
22 The Lord Jesus Christ be with thy spirit. Grace be with you. Amen. [The second epistle unto Timotheus, ordained the first bishop of the church of the Ephesians, was written from Rome, when Paul was brought before Nero the second time.]