Then said he, Knowest thou wherefore I come unto thee? and now will I return to fight with the prince of Persia: and when I am gone forth, lo, the prince of Grecia shall come.
Then said he, Knowest thou wherefore I come unto thee? The angel asks, after Daniel had recovered from his fright, whether he has understood what was revealed (Daniel 10:13). On Daniel by his silence intimating that he did understand, the angel declares he will return to renew the fight with the evil angel, the prince of Persia. This points to new difficulties to the Jews' restoration, which would arise in the Persian court, but which would be counteracted by God through the ministry of angels.
And when I am gone forth, lo, the prince of Grecia shall come - Alexander the Great, who conquered Persia, and favoured the Jews (Calvin). Rather, as the prince of Persia is an angel, representing the hostile world-power, so the prince of Grecia is a fresh angelic adversary, representing Greece. When I am gone forth from conquering the Persian foe, a fresh one starts up-namely, the world-power that succeeds Persia, Greece-Antiochus Epiphanes, of whom he proceeds accordingly to foretell in the next chapter, and his antitype, Antichrist; but him, too, with the help of Michael, Israel's champion, I shall overcome (Gejer).