For I will rise up against them, saith the LORD of hosts, and cut off from Babylon the name, and remnant, and son, and nephew, saith the LORD.
I will rise up against them - the family of the King of Babylon.
And cut off from Babylon the name - all the male representatives, so that the name shall become extinct (Isaiah 56:5; Ruth 4:5).
And remnant, and son, and nephew - all that is left of them. The dynasty shall cease (notes, Daniel 5:2; Daniel 5:28-31). Compare as to Babylon in general, Jeremiah 51:62.