Thus shall they be unto thee with whom thou hast laboured, even thy merchants, from thy youth: they shall wander every one to his quarter; none shall save thee. Thus shall they be unto thee with whom thou hast laboured - Such shall be the fate of those astrologers who cost thee such an amount of trouble and money.
Thy merchants, from thy youth - i:e., with whom thou hast trafficked from thy earliest history: the foreigners sojourning in Babylon for the sake of commerce (Isaiah 13:14; Jeremiah 51:6; Jeremiah 51:9; Nahum 3:16-17) (Barnes). Rather, the astrologers, with whom Babylon had so many dealings (Isaiah 47:12-14) (Horsley).
To his quarter (Hebrew, le'ebro) - literally, straight before him (Ezekiel 1:9; Ezekiel 1:12). The foreigners, whether soothsayers or merchants, shall flee home out of Babylon (Jeremiah 50:16).
Remarks: The world-power, now so proud, shall at last, like Babylon of old, be abased to the dust. Instead of glory it shall have "shame." When God shall "take vengeance," He will "not meet" the adversary "as a man." But the people of God have as their "Redeemer the Lord of hosts ... the Holy One of Israel." After He hath sufficiently chastised Israel in His wrath, by the hand of the world-power, He will take vengeance on it for its merciless cruelty to His people. The world-power thinks to be "The lady of kingdoms ... forever" (Isaiah 47:5; Isaiah 47:7), and so will 'not lay to heart' or "remember" what God hath said as to "the latter end of it."