Then shalt thou call, and the LORD shall answer; thou shalt cry, and he shall say, Here I am. If thou take away from the midst of thee the yoke, the putting forth of the finger, and speaking vanity;
Then shalt thou call, and the Lord shall answer. When sin is renounced (Isaiah 65:24). When the Lord's call, is not hearkened to, He will not hear our "call" (Psalms 66:18; Proverbs 1:24; Proverbs 1:28; Proverbs 15:29; Proverbs 28:9).
If thou take away from the midst of thee the yoke - (cf. note, Isaiah 58:6.)
The putting forth of the finger - the finger of scorn pointed at simple-minded godly men. The middle finger was so used by the Romans.
And speaking vanity - every injurious speech (Lowth).