At the noise of the stamping of the hoofs of his strong horses, at the rushing of his chariots, and at the rumbling of his wheels, the fathers shall not look back to their children for feebleness of hands;
At the noise of the stamping of the hoofs of his strong horses - (cf. Jeremiah 4:29, "The whole city shall flee from the noise of the horsemen").
Fathers shall not look back to ... children - each shall think only of his own safety, not even the fathers regarding their own children. So desperate shall be the calamity that men shall divest themselves of the natural affections.
For feebleness of hands - the hands, the principal instrument of action, shall have lost all power; their whole hope shall be in their feet.