Thus saith the LORD; Behold, I will raise up against Babylon, and against them that dwell in the midst of them that rise up against me, a destroying wind;
Against them that dwell in the midst of them that rise up against me - literally, in the heart of them, etc. Compare Psalms 46:2, "the midst of the sea" - margin, 'the heart of the seas;' Ezekiel 27:4, margin; Matthew 12:40, "in the heart of the earth" - in the center of the Chaldeans. They "rise up against me," because they persecute my people. The Athbash or cabalistic mode of interpreting Hebrew words (by taking the letters in the inverse order of the alphabet, the last letter representing the first, and so on, Jeremiah 25:26, "Sheshach") would give the very word Chaldeans for "in the midst of them that rise up against me" х leeb (H3820) qaamaay (H6965)] here; but the mystical method cannot be intended, as "Babylon" is plainly so called in the immediately preceding parallel clause.
A destroying wind. God needs not warlike weapons to "destroy" His foes; a wind or blast is sufficient; though, no doubt, the "wind" here is the invading host of Medes and Persians (Jeremiah 4:11; 2 Kings 19:7).