He will regard the prayer of the destitute, and not despise their prayer.
He will regard the prayer of the destitute - the confident anticipation of the answer to Psalms 102:1. The restoration of Zion shall be the result of the earnest prayers of Yahweh's people in their distress (cf. Psalms 102:25; Isaiah 62:6-7). So the restoration from Babylon was the fruit of the prayers of Nehemiah (Nehemiah 1:4-11), Daniel (Daniel 9:1-27), and other servants of God. "Destitute" х haa`ar`aar (H6199), probably a form coined by the Psalmist: akin to `aarar (H6209), bare: cf. Psalms 137:7, margin] - one utterly naked of all human help.
And not despise their prayer - (Psalms 22:5; Psalms 69:33.)