Saying to the sixth angel which had the trumpet, Loose the four angels which are bound in the great river Euphrates.
In, х epi (G1909) too (G3588) potamoo (G4215)] - 'ON,' or 'AT, the great river.'
Euphrates (cf. Revelation 16:12) - whereat Babylon, the ancient foe of God's people, was situated. Again, whether from the literal Euphrates (the boundary between Israel and the great world-kingdom), or from spiritual Babylon (the apostate church, especially ROME), four angelic ministers of God's judgments shall go forth, assembling horsemen throughout the four quarters of the earth, to slay a third of men. The brunt shall be on Palestine.