That I have great heaviness and continual sorrow in my heart.
That I have great heaviness and continual sorrow ('great grief and unceasing anguish') in my heart - the bitter hostility of his nation to the glorious Gospel, and the awful consequences of their unbelief, weighing heavily and incessantly upon his spirit. The grace which revolutionized the apostle's religious views and feelings did not (we see) destroy, but only intensified and elevated his natural feelings; and Christians should study to show that the same is true of them also.