Behold the nations, &c. As the drop of a bucket is as nothing when compared with the waters of the immense ocean, so all the nations of the world are as nothing when compared with God; and are counted by him, and in comparison of him, as the small dust which accidentally cleaves to the balance, but makes no alteration of the weight. Behold, he taketh, up the isles, &c. Those numerous and vast countries, to which they went from Judea by sea, which are commonly called isles in the Scriptures. And Lebanon is not sufficient to burn, &c. Although he is pleased to accept poor and small sacrifices from his people, yet, if men were to offer a sacrifice suitable to his infinite excellency, the whole forest of Lebanon could not afford either a sufficient number of beasts to be sacrificed, or a sufficient quantity of wood to consume the sacrifice. All nations before him In his eyes, or being set against him, as נגדו properly and usually signifies; are as nothing In his judgment; or in comparison of him; less than nothing Less than a thing of naught, or of no account or worth.
Related Commentaries of Isaiah 40:15
Isaiah 40:15-17
15 Behold, the nations are as a drop of a bucket, and are counted as the small dust of the balance: behold, he taketh up the isles as a very little thing.
16 And Lebanon is not sufficient to burn, nor the beasts thereof sufficient for a burnt offering.
17 All nations before him are as nothing; and they are counted to him less than nothing, and vanity.