The churches of Asia - The word “Asia” in the New Testament usually denotes Asia Minor in general; see the note on Acts 2:9. It was sometimes used in a more limited sense, to denote the region around Ephesus, and of which Ephesus was the center and capital; see note, Acts 16:6. This is the region undoubtedly which is intended here.
Salute you - Greet you; send respectful and affectionate Christian regards; see the note at Romans 16:3.
Aquila and Priscilla - See the note on Acts 18:26.
Much in the Lord - With affectionate Christian salutations; or as Christians. Wishing the blessing and favor of the Lord.
With the church that is in their house - See the note at Romans 16:5.