1 Corinthians 16:19 - Matthew Poole's English Annotations on the Holy Bible

He meaneth the Lesser Asia, in which was Ephesus; from whence it is more probable (according to the Arabic and Syriac opinion) that this Epistle was written, than from Philippi (according to the copy followed by our translaters). And that which further adds to that probability is, that the apostle mentioneth the salutations of Aquila and Priscilla, as persons that were at that time with him; now, that they lived at Ephesus, or at least went thither with Paul, and tarried there, appeareth from Acts 18:19: their saluting the church of Corinth in the Lord, signifies their wishing them all spiritual blessings in and from Christ. But what is meant by the church in their house, which joined with Paul in this salutation, is not so plain: we read the like, Colossians 4:15, of the church in Nymphas's house; and in Philemon's house, Philemon 1:2; and the same again of this Aquila and Priscilla, Romans 16:5. Some think that it signifieth no more, than that their whole families had received the Christian faith; others think, that divers other Christians sojourned with them; others, that the church was wont to meet in some room in their house: but the last is not probable, either that in those times the church kept their meetings in any one stated place, or that Christians then had such spacious houses as could afford a room large enough for the whole church to meet in.