For thus saith the Lord unto the eunuchs - Even the eunuchs, who have hitherto been excluded from the privileges of the people of God, and who have been regarded as a separated and degraded people, shall be admitted to the same privileges as others.
That keep my sabbaths - The word is used here in the plural, though the weekly Sabbath is probably particularly intended. It may be, however, that the word is used to represent religious observances in general (see the notes at Isaiah 56:2).
And choose the things that please me - Who will be willing to sacrifice their own pleasure and preferences to those things which I choose, and in which I delight.
And take hold of my covenant - Hold fast, or steadily maintain my covenant. On the meaning of the word ‘covenant,’ see the notes at Isaiah 28:18; Isaiah 42:6; Isaiah 49:8; Isaiah 54:10.