Have estranged this place - They have not recognized the sanctity of this place, but have treated it as a strange place, by worshipping in it strange gods.
Innocents - i. e., guiltless persons.
Related Commentaries of Jeremiah 19:4
Jeremiah 19:4
4 Because they have forsaken me, and have estranged this place, and have burned incense in it unto other gods, whom neither they nor their fathers have known, nor the kings of Judah, and have filled this place with the blood of innocents;