Have estranged this place. — i.e., have alienated it from Jehovah its true Lord, and given it to a strange god. The words refer specially to the guilt of Manasseh (2 Chronicles 33:4).
The blood of innocents. — The words seem at first to refer to the Molech sacrifices, which had made the valley of Hinnom infamous. These, however, are mentioned separately in the next verse, and the prophet probably spoke rather here, as in Jeremiah 2:34; Jeremiah 7:6, of the “innocent blood” with which Manasseh had filled Jerusalem (2 Kings 21:16; 2 Kings 24:4, where the same word is used).