Burden - Here a prophecy, either
(1) as being something weighty: or
(2) a something said aloud.
Isaiah brought the word into general use: Jeremiah never used it, though his predictions were all of impending evil. The false prophets, however, applied it in derision to Jeremiah’s prophecies, playing upon its double sense, and so turning solemn realities into mockery (see Jeremiah 23:34).
What burden? - Or, according to another reading, Ye are the burden.
I will even forsake you - Rather, and I will cast you away. From the idea of a burden the thought naturally arises of refusing to bear it, and throwing it off.