Let them be confounded - That is, Let them, through Thy gracious interposition in my behalf, be so entirely overcome and subdued that they shall be “ashamed” that they ever made the effort to destroy me; let them see so manifestly that God is on my side that they will be covered with confusion for having opposed one who was so entirely the object of the divine protection and care. See Psalms 6:10, note; Psalms 25:2-3, notes. Compare the notes at Job 6:20.
That seek after my soul - My life. That seek to destroy me.
Let them be turned back - In their attempts to pursue me. Do thou interpose and turn them back.
And brought to confusion - Put to shame; or made ashamed - as they are who are disappointed and thwarted in their schemes.