Deliver me from all my transgressions - Recognising, as in Psalms 38:3-5, his sins as the source of all his troubles and sorrows. If his transgressions were forgiven, he felt assured that his trouble would be removed. His first petition, therefore, is, that his sins might be pardoned, with the implied conscious assurance that then it would be consistent and proper for God to remove his calamity, and deliver him from the evils which had come upon him.
Make me not the reproach of the foolish - Of the wicked; of those who are foolish, because they are wicked. See the notes at Psalms 14:1. The prayer here is, that God would not suffer him to become an object of reproach to wicked and foolish men; that is, as the passage implies, that God would not so continue to treat him as if he were a sinner as to justify to themselves their reproaches of him as a wicked man. In other words, he prays that God would forgive his sin, and would withdraw his hand of affliction, so that even the wicked might see that he was not angry with him, but that he was an object of the divine favor.