Isaiah 53:4 - Ellicott's Commentary On The Whole Bible

Surely he hath borne our griefs... — The words are spoken as by those who had before despised the Servant of Jehovah, and have learnt the secret of His humiliation. “Grief” and “sorrow,” as before, imply “disease” and “pain,” and St. Matthew’s application of the text (Matthew 8:17) is therefore quite legitimate. The words “stricken, smitten of God,” are used elsewhere specially of leprosy and other terrible sicknesses (Genesis 12:17; Leviticus 13:3; Leviticus 13:9; Numbers 14:12; 1 Samuel 6:9; 2 Kings 15:5). So the Vulg. gives leprosus. The word for “borne,” like the Greek in John 1:29, implies both the “taking upon himself,” and the “taking away from others,” i.e., the true idea of vicarious and mediatorial atonement.