Psalms 134:2 - Ellicott's Commentary On The Whole Bible

Lift up your hands (see Note, Psalms 28:2) (in) the sanctuary. — The usual meaning would be to the sanctuary (see reference above), but since the servants of Jehovah are here addressed as standing in the sanctuary, this direction seems unreasonable. Render, therefore, in holiness, and comp. “lifting up holy hands” (1 Timothy 2:8).