‘And do not be drunk with wine which results in riotous behaviour (or wastefulness), but be being filled in (or ‘by') the Spirit.'
Continuing his contrasts which are a feature of Ephesians 4:22 to Ephesians 5:21, bringing out the contrast between the old man and the new man (Ephesians 4:22-24), Paul points out that the old man looks to drink for his consolation but the new man looks to the Holy Spirit. Thus they are not to get tipsy but are to continually drink of the heavenly wine which is provided by the Holy Spirit (compare 1 Corinthians 12:13; John 7:37-39). It is something they must go on doing continually, enjoying the continual flow of God's blessing by looking to Jesus Christ (John 7:37) for their sustenance, and drinking of His word as the instrument of His Spirit. Note how in Colossians this spiritual singing in the heart results from ‘the word of Christ dwelling in them richly in all wisdom' (Colossians 3:16).
This is the only use of ‘filled by the Spirit' (plerousthe en Pneumati) in the New Testament. (‘En' never means ‘with'. It means ‘in' or ‘by').
Luke, in Luke and Acts, uses the verb pimplemi followed by ‘of the Holy Spirit' (Luke 1:15; Luke 1:41; Luke 1:67; Acts 2:4; Acts 4:8; Acts 4:31; Acts 9:17; Acts 13:9) and in his case the phrase is always describing inspired words to be explained in terms of the Spirit's working, and is usually temporary to that occasion. The exceptions are in the cases of John the Baptiser (Luke 1:17), the disciples (Acts 4:31) and Paul (Acts 9:17). The Acts 2 experience as a whole was, of course, permanent, but the actual phrase ‘filled of the Holy Spirit' applied to the vocal phenomenon specifically referred to on that occasion.
The phrase ‘full of Holy Spirit' is used of Jesus (Luke 4:1) as a more permanent experience (it is also used of Stephen in Acts 7:55).
‘Pleroo' is used followed by ‘of the Holy Spirit' in combination with some spiritual attribute in Acts 6:3 (‘and wisdom'); Acts 6:5 (and ‘of faith'); Acts 11:24 (‘and of faith'); Acts 13:52 (and ‘with joy') to explain in each case some spiritual attribute. So pimplemi signifies being filled to utter inspired words in the proclamation of God's truth and pleroo signifies the possession of spiritual attributes resulting from the presence of the Spirit.
Here in Ephesians the pattern is followed but the verb is in the present tense and the attributes are as in Acts 13:19. The Christian life is to be one of continual worship and praise through the infilling work of the Spirit.