Isaiah 43:28 - Matthew Poole's English Annotations on the Holy Bible

I have profaned; as they have made themselves profane, so I have dealt with them as such, without any regard to the sacredness and dignity of their functions. I have exposed them to contempt and destruction. The princes of the sanctuary; the highest and best of your priests, whose persons were most sacred, and therefore supposed by themselves and others to be the furthest from danger. To the curse; to utter destruction, to which persons or things accursed were devoted, of which this Hebrew word is constantly used. To reproaches; to be the objects of their enemies scorn and reproaches.