Isaiah 65:25 - Matthew Poole's English Annotations on the Holy Bible

This verse containeth a promise much like that Isaiah 11:6,9, and relates to the ceasing of persecution. The people of God for their whiteness and innocency are often compared to lambs and sheep, wicked men to wolves and lions, for their antipathy to the seed of the woman: God here promiseth to take off the fierceness of the spirits of his people's enemies, so that they shall live quietly and peaceably together. Wicked men are compared to serpents, Micah 7:17, compared with Psalms 72:9; God promiseth a time of tranquillity to his church under the metaphor of serpents eating the dust, their proper meat, Genesis 3:14, instead of flying upon men: it signifies such a time when wicked men should mind their proper business, and not make it their work to eat up the people of God like bread. For the last phrase, see Isaiah 11:9, what is there noted. But will some say, When shall these things be? The Scripture gives us no record of any such period of time yet past. And it is very probable that this is a promise yet to be fulfilled, and it is not for us to know the times and seasons, but in the mean time to let our faith and patience be seen. In the mean time, we may learn that it is God's work to restrain the wolves and serpents of the world, who would else be always doing what they are sometimes doing; and it is a sad sign that God is not yet at peace with that people, where we see wolves devouring lambs, and serpents destroying men instead of licking up dust, nor well-pleased with that part of his holy mountain where there is nothing but hurting and destroying, biting and devouring one another. When God shall be at peace with a people, these things shall not be found amongst them.