John 2:4 - Matthew Poole's English Annotations on the Holy Bible

That it was ordinary with the Jews, speaking to women, to call them by the name of their sex, is plain from Matthew 15:28 Luke 13:12 Luke 22:57 1 Thessalonians 4:21. But that, speaking to their relations, they were wont to own their relation in their compellation, sometimes is also evident, from 1 Kings 2:20, Ask on, my mother. So as our Saviour's here calling the blessed virgin, Woman, not mother, is agreed by most to signify to her, that in this thing he did not own her as his mother, and so clothed with an authority to command him. And indeed so much the next words ( what have I to do with thee?) signify, which is a form of speech that both signifies some displeasure for her unseasonable interrupting him, and also that she had no right nor authority upon him in this thing. See the use of the same phrase, Judges 11:12 2 Samuel 16:10 Ezra 4:3 Matthew 2:29; Matthew 8:19. None was more obedient and respective to his parents than our Saviour, Luke 2:51, therein fulfilling the will of God, Jeremiah 35:13,14; but in the business of his calling he regarded them not, Matthew 12:48 Luke 2:49; and hath hereby taught us our duty, to prefer our obedience to our heavenly Father before our obedience to any earthly relation, Matthew 5:37 Luke 14:26. He hath also hereby taught us, that the blessed virgin is not to be preferred before her Son (as the papists do). Besides this, our Lord giveth another reason for his not present hearkening to his mother, mine hour is not yet come; either, because the time was not yet come to work miracles publicly; or to show her, that she was not to prescribe the time to him when he should work miraculously; thereby also showing us, that for things in this life we are to submit our desires to the Divine will, and to wait God's leisure; yet by this expression he also gives her some hopes that he would in his own time supply this want.