Psalms 69:21 - Matthew Poole's English Annotations on the Holy Bible

Gall, or poison, or bitter herbs, Hosea 10:4. See Deuteronomy 29:18 Jeremiah 9:15 Lamentations 3:19. Instead of giving me that pity and comfort which my condition required, they barbarously added to my afflictions. These things were metaphorically fulfilled in David, but properly and literally h Christ, the description of whose sufferings was principally intended here by the Holy Ghost, who therefore directed David's pen to these words, and possibly informed him that this should be accomplished in Christ; which may not seem improbable to him that considers the following imprecations, which are so many and so severe, that they may seem to exceed the bounds of justice and charity, if they be applied to David's enemies, as a recompence for their injuries done to him; whereas they most deservedly and fitly belong to the enemies and murderers of Christ.