For your hands are defiled— The prophet here goes on to specify those iniquities which he had mentioned in general, and in such an order, that he distributes them, as it were, through the members of the human body; the hands, the mouth, the feet; dwelling longest, however, upon the faults committed by the mouth; which are set forth literally and properly, first, in the middle of Isaiah 59:3-4 and then figuratively, Isaiah 59:5-6. The meaning of the expression, They hatch cockatrice' eggs, is, "Their wicked designs are like the eggs of a cockatrice, rank poison, which, when hatched, produce a venomous serpent: they end in destruction and misery." The expression of weaving the spider's web, signifies, "They attempt things, which meet with no success." See Job 8:14. The 4th verse may be rendered, No one pleadeth in righteousness, &c. In Isaiah 59:8 instead of there is no judgment in their goings, Vitringa reads, there is no regard to right in their goings.
Isaiah 59:3-8
3 For your hands are defiled with blood, and your fingers with iniquity; your lips have spoken lies, your tongue hath muttered perverseness.
4 None calleth for justice, nor any pleadeth for truth: they trust in vanity, and speak lies; they conceive mischief, and bring forth iniquity.
5 They hatch cockatrice' eggs, and weave the spider's web: he that eateth of their eggs dieth, and that which is crushed breaketh out into a viper.
6 Their webs shall not become garments, neither shall they cover themselves with their works: their works are works of iniquity, and the act of violence is in their hands.
7 Their feet run to evil, and they make haste to shed innocent blood: their thoughts are thoughts of iniquity; wasting and destructionb are in their paths.
8 The way of peace they know not; and there is no judgmentc in their goings: they have made them crooked paths: whosoever goeth therein shall not know peace.