Lest my soul depart from thee— That is to say, "Lest my affections be utterly alienated from thee, so that I cast off all bowels of compassion towards thee, and give thee up to ruin and desolation." Houbigant renders it, Lest my soul be alienated, &c. See Psalms 81:12-13 and chap Jeremiah 51:9.
Related Commentaries of Jeremiah 6:8
Jeremiah 6:8
8 Be thou instructed, O Jerusalem, lest my soul departc from thee; lest I make thee desolate, a land not inhabited.