My liver, &c.— Bishop Lowth explains it, "My vitals seem to be dissolved, and have lost all their strength." See Job 16:13.Psalms 22:14. The LXX. read My glory is cast down upon the ground. That the mental passions have a considerable influence upon the habit of the body in various instances, is a fact not to be questioned. And experience daily shews, that a violent uneasiness of mind tends greatly to promote a redundancy and overflowing of vitiated bile. The liver is the proper seat of the bile, where its secretions are carried on. Hence the prophet's meaning in this place seems to be, that he felt as if his whole liver was dissolved, and carried off in bile, on account of the copious discharge brought on by continual vexation and fretting. Job expresses the same thing, when he says, Job 16:13. "He poureth out my gall upon the ground."
Related Commentaries of Lamentations 2:11
Lamentations 2:11
11 Mine eyes do fail with tears, my bowels are troubled, my liver is poured upon the earth, for the destruction of the daughter of my people; because the children and the sucklings swoonf in the streets of the city.