Who can have compassion on the ignorant, and on them that are out of the way; for that he himself also is compassed with infirmity.
Who can - `Being one able:' not pleasing himself (Romans 15:3).
Have compassion, х metriopathein (G3356)] - 'feel leniently (moderately) toward:' 'to make allowance for:' not showing stern rigour save to the obstinate (Hebrews 10:28).
Ignorant - sins not committed in resistance of light and knowledge, but as Paul's past sin (1 Timothy 1:13). No sacrifice was appointed for willful sin committed with a high hand; such were to be put to death: all other sins-namely, ignorances and errors-were confessed and expiated with sacrifices by the high priest.
Out of the way - not deliberately and determinately erring, but deluded through the fraud of Satan and their own carnal frailty.
Infirmity - moral weakness, which, being sinful, and making men capable of sin, requires to be expiated by sacrifices. This "infirmity" Christ had not: He had the "infirmity" of body whereby He was capable of suffering and death.