Go up against the land of Merathaim, even against it, and against the inhabitants of Pekod: waste and utterly destroy after them, saith the LORD, and do according to all that I have commanded thee.
The land of Merathaim - a symbolical name for Babylon, the doubly rebellious, namely, against God. Compare the description of Babylon in Jeremiah 50:24, "Thou hast striven against the Lord;" and Jeremiah 50:29, "proud against the Lord." The 'doubly' refers to, first, the Assyrian's oppression of Israel, next, the kindred Chaldean's oppression of Judah (cf. Jeremiah 50:17-20; Jeremiah 50:33; especially Jeremiah 50:18).
Against the inhabitants of Pekod - (Ezekiel 23:23) a chief province of Assyria, in which Nineveh, now overthrown, once lay. But, as in Merathaim, the name is used symbolically in allusion to its meaning, so the allusion is to the meaning of Pekod, namely, visitation; the inhabitants whose time of deserved visitation in punishment is come; not, however, without reference to the now Babylonian province Pekod. The visitation on Babylon was a following up of that on Assyria.
Utterly destroy after them - even their posterity, and all that is still left of Babylon, until the very name is extinct (Grotius). Devastate the city, after its inhabitants have deserted it.
Do according to all that I have commanded - by Isaiah, (Isaiah 13:1, etc.)