Compare Jeremiah 2:30; Hebrews 11:37; Isaiah 57:1-4. According to tradition, Isaiah was among the first to perish. More than a century afterward, the final judgment upon Jerusalem was felt to be in an special way the punishment of Manasseh’s bloody persecution of God’s people (marginal reference).
Related Commentaries of 2 Kings 21:16
2 Kings 21:16
16 Moreover Manasseh shed innocent blood very much, till he had filled Jerusalem from one end to another; beside his sin wherewith he made Judah to sin, in doing that which was evil in the sight of the LORD.