Blood — The blood of those prophets and righteous men who either reproved his sinful practices, or refused to comply with his wicked commands. His sin — His idolatry, which is called sin, by way of eminency. The tradition of the Jews is, that he caused Isaiah in particular to be sawn asunder.
Related Commentaries of 2 Kings 21:16
2 Kings 21:16
16 Moreover Manasseh shed innocent blood very much, till he had filled Jerusalem from one end to another; beside his sin wherewith he made Judah to sin, in doing that which was evil in the sight of the LORD.