The second poured out his phial upon the sea — As opposed to the dry land. And it become blood, as of a dead man — Thick, congealed, and putrid. And every living soul — Men, beasts, and fishes, whether on or in the sea, died.
Related Commentaries of Revelation 16:3
Revelation 16:3
3 And the second angel poured out his vial upon the sea; and it became as the blood of a dead man: and every living soul died in the sea.